Nobel University was founded in the summer of 2000 in Los Angeles, California. Committed to producing quality practitioners of Oriental Medicine, the school began by offering a master’s degree program in acupuncture – Master of Science in Oriental Medicine (MSOM).

In 2003, the Bureau for Private Postsecondary Education approved the school to offer a certificate ESL program, and in 2004, the Bachelor of Arts in Business Administration (BA) and Master of Business Administration (MBA) programs. In 2006, the Bachelor of Arts in Church Music program (BCM) was added.

In 2009, the branch campus in the city of Buena Park, California was established to accommodate the growing student body.

In 2013, the school shifted its strategic plan and its focus by concentrating on its business program offerings. Since the school discontinued offering the ESL, BCM, and MSOM programs, it specialized in business administration to deliver world-class business education for its students.